GROUP A STREPTOCOCCAL POLYSACCHARIDE IMMUNOGENIC COMPOSITIONS AND METHODS

摘要

This invention provides a novel immunogenic composition and vaccine, process es for producing them and methods for immunization against infections and disease caused by group A Streptococci. The compositi ons include group A streptococcal polysaccharide covalen tly linked to protein or liposomes to form immunogenic conjugates. The method of immunization for this invention comprises administering to an individual an immunogenic amount of group A polysaccharide. The group A p olysaccharide may be administered as a vaccine either on its own, conjugated to proteins or conjugated to liposomes. Additionally, th e group A polysaccharides may be associated with an adju vant. This invention is particularly useful for providing both active and passive immunogenic protection for those populations most at ris k of contracting group A Streptococcal infections and disease namely adults, preg nant women and in particular infants and children.