Liposomes for tumour therapy

摘要

An agent for tumour therapy in the form of liposomes contains a phospholipid analogue and cholesterol and a polyethylene glycol modified lipid (PEG-lipid). Pref. the phospholipid is of formula R-X-P-Y (I) or CH2OR-CHZ-CH2OPc (II). R = 12-22C alkyl, alkenyl or alkynyl; X = O or S; Y = choline or modified choline, serine or ethanolamine gp.; Z = halogen or OMe; Pc = phosphocholine or modified phosphocholine. The PEG-lipid is polyethylene glycol-modified phosphatidyl ethanolamine of mol. wt. 1000-6000.