发明名称 |
DETECTION OF MUTATION BY RESOLVASE CLEAVAGE |
摘要 |
Methods are disclosed for detecting one or more mutations in an isolated test nucleic acid for forming a heteroduplex with a homologous control DNA and contacting the heteroduplex with a resolvase capable of recognizing at least one single base pair mismatch within the heteroduplex. In preferred embodiments of the invention, the resolvase is bacteriophage T4 endonuclease VII. |
申请公布号 |
CA2188660(A1) |
申请公布日期 |
1995.11.02 |
申请号 |
CA19952188660 |
申请日期 |
1995.04.21 |
申请人 |
AVITECH DIAGNOSTICS, INC. |
发明人 |
COTTON, RICHARD G.H.;YOUIL, RIMA;KEMPER, BORRIES W. |
分类号 |
G01N33/50;C12N15/09;C12Q1/68;(IPC1-7):C12Q1/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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