ANGIOSTATIN PROTEIN, NUCLEIC ACIDS ENCODING THE SAME AND METHODS OF DETECTION

摘要

The present invention comprises an endothelial inhibitor and method of use therefor. The endothelial inhibitor is a protein isolated from the blood or urine that is eluted as a single peak from C4-reverse phase high performance liquid chromatography. The endothelial inhibitor is a molecule comprising a protein having a molecular weight of between approximately 38 kilodaltons and 45 kilodaltons as determined by reducing polyacrylamide gel electrophoresis and having an amino acid sequence substantially similar to that of murine plasminogen fragment beginning at amino acid number 98 of a murine plasminogen molecule.