Aminosulphonyl-phenyl-1h-pyrrole derivatives method of their preparation and their use

摘要

Compounds of formula (I) wherein R<1> represents C1-4alkyl; one of R<2>, R<3>, R<4> and R<5> represents a sulphonamido group R<6>R<7>NSO2-, wherein either: R<6> represents hydrogen, C1-6alkyl, or C1-4alkoxyC1-4alkyl; and R<7> represents a group (R)p-(Ar)-(CH2)j- wherein Ar represents phenyl, naphthyl, a 5- or 6-membered heterocyclic aryl group, or a 5- or 6-membered heterocyclic aryl group fused to a phenyl ring; j represents zero or an integer from 1-4; R represents a substituent selected from halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, nitro, cyano, trifluoromethyl, trifluoromethoxy, hydroxy, hydroxyC1-4alkyl, C1-4alkanoyl, C1-4alkoxycarbonyl, amino, mono- or -di-C1-4alkylamino, C1-4alkylthio, C1-4alkylsulphinyl, C1-4alkylsulphonyl and phenylC1-4alkoxy; and p represents zero or an integer from 1-4; or R<6>R<7>N- represents a 5-7 membered heterocyclic ring which is fused to or substituted by a phenyl group, or substituted by a 5- or 6-membered heterocyclic aryl group, said phenyl or heteroaryl group being optionally substituted by a group (R)p, wherein R and p are as defined hereinabove; and Y represents a group selected from (a) - (e); and salts thereof, have activity at dopamine receptors and are potentially useful in the treatment of psychoses such as schizophrenia.