CONTROLLED RELEASE BIODEGRADABLE MICROSPHERES AND METHOD OF PREPARATION
摘要
Method for the preparation of a pharmaceutical composition in the form of microspheres controllably releasing at least one water soluble active ingredient. The method comprises the steps of dissolving the active ingredient in a suitable quantity of water; emulsifying the aqueous solution containing the active ingredient with a solution of at least a d,l-lactide-co-glycolide-type matrix copolymer in chlorinated hydrocarbon further containing a low molecular weight polyactide release modulating agent, which results in a first microfine and homogeneous emulsion; emulsifying the first emulsion thus obtained in an external aqueous phase, containing a surface active agent; and removing and evaporating the solvent to produce microspheres which are recovered after filtering, washing and drying.
申请公布号
WO9528149(A1)
申请公布日期
1995.10.26
申请号
WO1995FR00485
申请日期
1995.04.13
申请人
PIERRE FABRE MEDICAMENT;AROLA, ROSA;ASIN, MIGUEL, ANGEL;FERRET, EULALIA;GOUTAY, ERIC;PEREZ, AMADEO;TARIN, PERE
发明人
AROLA, ROSA;ASIN, MIGUEL, ANGEL;FERRET, EULALIA;GOUTAY, ERIC;PEREZ, AMADEO;TARIN, PERE