| 摘要 |
A novel platinum complex (II) represented by general formula (A) and a remedy for malignant tumor containing the same as the active ingredient, wherein R1 represents a C1-C3 lower hydrocarbon group; R2 and R3 represent each independently hydrogen or a C1-C3 lower hydrocarbon group, or R2 and R3 may be combined together to represent -(CH2)4- or -(CH2)5-; Y and Z represent each independently ammonia or a monodentate amine having a C1-C7 hydrocarbon group, or Y and Z may be combined together to represent a didentate diamine having a C2-C10 hydrocarbon group; and X- represents an inorganic acid anion or an organic carboxylic acid anion. This compound is efficacious against cisplatinresistant cancer, has a solubility suitable for intravenous administration, is stable in aqueous solution, and has an excellent antitumor activity.
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