| 摘要 |
There is provided novel sulfated alpha -glycolipid compounds of the formula <CHEM> wherein R is an acyl residue of a fatty acid; R<1> is -(CH=CH)m-(CH2)n-CH3; R<2>, R<3>, R<4> and R<6> are independently at least two -SO3H; R<2>, R<3>, R<4> R<5> and R<6> each are independently hydrogen, unsubstituted or substituted alkanoyl, arylalkyl or arylcarbonyl wherein said substituent is selected from halogen, C1-4 alkyl, trifluoromethyl, hydroxy and C1-4 alkoxy; m is an integer of 0 or 1; n is an integer of from 5 to 14, inclusive; or a non-toxic pharmaceutically acceptable salt, solvate or hydrate thereof which are inhibitors of selectin-mediated cellular adhesion and are useful in the treatment or prevention of inflammatory diseases and other pathological conditions in mammals. |
