ARYLALKYLAMINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME

摘要

Arylalkylamine of formula: in which: - Y represents - either a group Cy-N in which Cy represents an optionally substituted phenyl; a C3-C7 cycloalkyl group; a pyrimidinyl group or a pyridyl group; - or a group in which . Ar represents an optionally substituted phenyl; a pyridyl group; a thienyl group; . x is 0 or 1; . X represents a hydroxyl, a C1-C4 alkoxy; a C1-C4 acyloxy; a carboxyl; a C1-C4 carbalkoxy; a cyano; a group -N-(X1)2 in which the X1 groups independently represent hydrogen or a C1-C4 alkyl; a group -S-X2 in which X2 represents hydrogen or a C1-C4 alkyl group; or else X forms, with the carbon atom to which it is bonded and with the neighbouring carbon atom in the heterocycle, a double bond; - m is 2 or 3; - Ar' represents an optionally substituted phenyl; a thienyl; a benzothienyl, a naphthyl or an indolyl; - R represents hydrogen or a C1-C6 alkyl; - T represents a group chosen from -CO- and -CW-NH- being an oxygen or sulphur atom, and - Z represents either hydrogen, or M or OM when T represents the -CO- group, or M when T represents the -CW-NH- group; M represents a C1-C6 alkyl; a phenylalkyl, a pyridylalkyl, a naphthylalkyl; a pyridylthioalkyl; a styryl; an optionally substituted mono-, di- or tricyclic heteroaromatic or aromatic group; or one of its salts with inorganic or organic acids. Application = antagonists of neurokinin receptors.