发明名称 |
Protein complexes having factor VIII:C activity and production thereof. |
摘要 |
Recombinant protein complexes having human Factor VIII:C activity are produced in a eukaryotic host cell by expressing a DNA construct encoding said protein complex joined in reading frame with control sequences providing for the expression of said DNA construct in said host cell, wherein said DNA construct comprises a nucleotide sequence that encodes a first polypeptide homologous to the A domain of human Factor VIII:C linked to a second polypeptide homologous to the C domain of human Factor VIII:C by a polypeptide spacer, wherein the polypeptide spacer is other than the full length B domain of human Factor VIII:C and comprises an amino acid sequence homologous to a human Ig heavy chain hinge region. |
申请公布号 |
EP0670332(A3) |
申请公布日期 |
1995.10.25 |
申请号 |
EP19950107535 |
申请日期 |
1990.11.15 |
申请人 |
NOVO NORDISK A/S;CHIRON CORPORATION |
发明人 |
CHAPMAN, BARBARA;BURKE, RAE LYN;RASMUSSEN, MIRELLA EZBAN;MIKKELSEN, JAN MOLLER |
分类号 |
C12N15/09;A61K38/00;A61K38/43;A61P7/00;A61P7/02;C07H21/04;C07K;C07K7/06;C07K14/00;C07K14/745;C07K14/755;C07K14/81;C07K16/00;C07K19/00;C12N;C12N5/10;C12N15/12;C12N15/62;C12N15/85;C12P;C12P21/02;C12R1/91 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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