| 发明名称 |
DIAGNOSTIC AND THERAPEUTIC ANTIBODY CONJUGATES. |
| 摘要 |
<p>A conjugate of methotrexate to an antibody is prepared by loading methotrexate onto an aminodextran, then specifically conjugating the polymer carrier to the carbohydrate portion of an antitumor antibody, using a reduced Schiff base linkage. The conjugate is useful for tumor targeted therapy.</p> |
| 申请公布号 |
EP0294392(B1) |
申请公布日期 |
1995.10.25 |
| 申请号 |
EP19870901952 |
申请日期 |
1987.02.25 |
| 申请人 |
CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY |
发明人 |
SHIH, LISA, B.;PRIMUS, F., JAMES;GOLDENBERG, M., DAVID |
| 分类号 |
G01N33/531;A61K39/00;A61K39/395;A61K45/00;A61K47/48;A61K49/00;A61K49/08;A61K51/00;A61K51/10;C07K1/113;C07K14/00;C07K14/415;C07K16/00;C07K17/08;C07K17/10;C07K19/00;G01N33/532;G01N33/543;G01N33/548;G01N33/574;(IPC1-7):C07K2/00;C07K17/06;A61K31/705;A61K39/44 |
主分类号 |
G01N33/531 |
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