摘要 |
This invention relates to bis-naphthalimides, including 2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione] and 2,2'-[1,2-ethanediylbis[imino(2-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-benz[de]isoquinoline-1,3(2H)-dione], processes for their preparation, pharmaceutical compositions containing them, and methods of using them to treat cancer in mammals.
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申请人 |
THE DU PONT MERCK PHARMACEUTICAL COMPANY |
发明人 |
SUN, JUNG-HUI;MATOS, JOSE R.;PARK, CHUNG-HO;CLIFTON, JR., ROBERT G. |