| 摘要 |
PURPOSE:To obtain a hydroxamic acid derivative expressed by a specific formula, having smooth muscle cell proliferation suppressive activity, effective as a vessel wall hyperplasia preventive, reconstriction preventive, or therapeutic agent for arteriosclerosis. CONSTITUTION:The objective derivative of formula I [R<1> is an aryloxy)phenyl or of formula II (R<3> is an aryl or an aryl 1-4C alkyl); L is a 1-8C alkylene, a 2-8C alkenylene, (CH2)m-O-((m) is 0 or 1-4) or CO; (n) is 0 or 1; R<2> is H, a 1-4C alkyl or an aryl 1-4C alkyl; M is H, an alkoyl, alkoxycarbonyl, etc.], e.g. N-benzyloxy-N-(1-phenylethyl)-4-[3-(4methoxyphenoxy)styryl]benzamide. This derivative is recommended to obtain by reaction of a carboxylic acid derivative of formula III with a carboxylic acid activator followed by reaction with a hydroxylamine derivative of formula IV (Z is H, benzyl, etc.). |
