| 摘要 |
The present invention relates to an indole derivative represented by formula (1) or a salt thereof, and a pharmaceutical containing the derivative or the salt: <CHEM> Äwherein R<1> represents lower alkyl; R<2> represents hydrogen or phenyl which may be substituted by at least one lower alkyl, lower alkoxy or a halogen atom; R<3> represents hydrogen, lower alkyl, lower alkoxy, or phenylalkyloxy which may be substituted by halogen or lower alkyl; R<4> represents hydrogen, lower alkyl or lower alkoxy; R<5> represents hydrogen or lower alkyl; and n represents an integer of 1 to 5Ü. This compound has the effects of both blocking alpha 1-adrenergic receptors and inhibiting testosterone 5 alpha -reductases, and is useful as a remedy and/or a preventive for diseases caused by dihydrotestosterone overproduction, such as prostatic hypertrophy, and diseases accompanying the same, such as urination disorder, male pattern alopecia, acne, and so forth. |
