| 摘要 |
A method of inhibiting human immunodeficiency virus type 1 (HIV-1) in a mammal using mammalian cells, particularly, human CD4 containing lymphocytes, which express chimeric RNA molecules containing HIV-1 psi signal and/or Gag coding sequences in antisense orientation. HIV-1 production was delayed up to 30 days when compared with control cells lacking the test DNA sequences. Retroviral vectors expressing the chimeric RNA molecules are provided.
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