| 摘要 |
The present invention provides a composition for use in raising a cellular and/or humoral immune response (mucosal and systemic) in mammals to an antigen. The composition comprises the antigen entrapped within liposomes with the liposomes being integrated into an ISCOM. It is preferred that the liposomes are formed using N-[1-(2,3-Dioleoyloxy)propal]-N,N,N-trimethyl-ammoniummethylsulfate (DOTAP). The composition may be administered via a number of routes including intradermal, intratracheal, intranasally, orally, rectally and by douche.
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