发明名称 |
Antibodies to Promoters of colony stimulating factor activity. |
摘要 |
<p>The present invention relates to the identification of promoters of myelopoietic blood cell production. In particular, an agent has been discovered that enhances myelopoietic colony stimulating factor activity. The agent comprises cytokines that are also capable of binding to heparin, and inducing localized inflammation characterized by polymorphonuclear cell infiltration when administered subcutaneously. Particular agents comprise the inflammatory cytokines MIP-1 and MIP-2. Diagnostic and therapeutic utilities are proposed, and pharmaceutical compositions are likewise set forth.</p> |
申请公布号 |
EP0409040(B1) |
申请公布日期 |
1995.10.18 |
申请号 |
EP19900113097 |
申请日期 |
1990.07.09 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
WOLPE, STEPHEN D.;CERAMI, ANTHONY;SHERRY, BARBARA |
分类号 |
G01N33/53;A61K38/00;A61K38/19;A61K39/395;A61K49/00;A61P7/00;C07K14/00;C07K14/52;C07K14/54;C07K16/00;C07K16/24;C12N5/0789;C12P21/02;C12P21/08;C12R1/91;G01N33/50;G01N33/577;(IPC1-7):A61K38/00;C12Q1/00 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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