发明名称 |
Recombinant adenoviruses coding for glial-derived neurotrophic factor (gdnf) |
摘要 |
Recombinant adenoviruses comprising a heterologous DNA sequence coding for glial-derived neurotrophic growth factor (GDNF) are provided. The recombinant adenoviruses are useful in a method of expressing GDNF in a cell, wherein the cell is present in a mammal suffering from Parkinson's disease, comprising infecting said cell with a replication-defective recombinant adenovirus comprising a DNA sequence encoding GDNF operably linked to a promoter by administering the adenovirus into cells of the central nervous system. The recombinant adenoviruses of the invention are also useful in a method of treating Parkinson's disease comprising administering into cells of the central nervous system of a mammal suffering therefrom a replication defective recombinant adenovirus comprising ITRs, an encapsidation sequence and a DNA sequence encoding GDNF operably linked to a promoter, wherein the adenovirus E1 gene is non-functional and GDNF is expressed at a level that provides a therapeutic effect. |
申请公布号 |
AU2141195(A) |
申请公布日期 |
1995.10.17 |
申请号 |
AU19950021411 |
申请日期 |
1995.03.23 |
申请人 |
RHONE-POULENC RORER S.A. |
发明人 |
PHILIPPE HORELLOU;JACQUES MALLET;MICHEL PERRICAUDET;FREDERIC REVAH;EMMANUELLE VIGNE |
分类号 |
C12N15/09;A61K9/00;A61K31/70;A61K35/76;A61K38/00;A61K38/17;A61K38/27;A61K47/48;A61K48/00;A61P25/00;A61P25/28;C07H21/04;C07K14/475;C12N5/10;C12N7/00;C12N15/861 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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