发明名称 |
NADH OXIDASE AS A TARGET IN DIAGNOSIS AND THERAPY |
摘要 |
Plasma membrane NADH oxidase is shown to be a target for a variety of uses in diagnotis and therapy. Particularly, the NADH oxidase associated with neoplastic cells is immunologically and biologically different from NADH oxidase associated with normal cells. Thus, the presence of tumor cells in patients can be monitored by monitoring serum or biopsy samples for the presence of disease associated NADH oxidase. By employing NADH oxidase as a target for inhibitors, tumor cells, virally infected cells and cells having multiple drug resistance may be specifically affected, while not affecting normal cells. Specific inhibitors having increased activity for disease associated NADH oxidase as compared to normal NADH oxidase are provided. The use of the NADH oxidase associated with tumor cells provides opportunities for assays for screening drugs that are specific for neoplastic cells and can serve as anticancer drugs or growth inhibitors.
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申请公布号 |
CA2187200(A1) |
申请公布日期 |
1995.10.12 |
申请号 |
CA19952187200 |
申请日期 |
1995.04.04 |
申请人 |
PORTOLA SCIENCES, INC. |
发明人 |
MORRE, D. JAMES;BYRN, STEPHEN R.;CRANE, FREDERICK L.;MORRE, DOROTHY M. |
分类号 |
A61K31/165;A61K38/44;A61K39/395;A61K45/00;A61P31/12;A61P35/00;A61P43/00;C07K16/10;C12N9/02;C12N9/99;C12P21/08;C12Q1/26;(IPC1-7):C07K16/40;A61K31/13;A61K31/16;A61K31/35;A61K47/48;A61K31/71 |
主分类号 |
A61K31/165 |
代理机构 |
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