摘要 |
Compounds represented by formula (I) (SEQ ID NO. 1) are disclosed, as well as pharmaceutically acceptable salts and hydrates thereof. R<I> represents C9 to C19 alkyl, C9 to C19 alkenyl, an aryl group which includes phenyl, biphenyl, naphthyl and terphenyl, or a C1 to C12 alkyl, alkylamino, dialkylamino or alkoxyaryl group. R<1>, R<2> and R<4> independently represent H or -OH. R<3> represents H, -OH, -O(CH2)nNR<V>R<VI>, where R<V> and R<VI> independently represent H or C1-4 alkyl, or -O(CH2)nNR<V>R<VI>R<VII>+Y-, wherein R<V> and R<VI> are as defined above, R<VII> represents H or C1-4 alkyl, n is an integer of from 2-6 inclusive, and Y represents a counterion. R<5> represents H, -CH3 or -OH; R<6> represents H or -CH3; R<7> represents H, -CH3, -CH2C(=O)NH2, -(CH2)2NR<V>R<VI> or -(CH2)2NR<V>R<VI>R<VII>+Y- with n, R<V>, R<VI>R<VII> and Y as defined above; and R<8> represents -Cl, -Br, -I, -NO2, -N3, -(CH2)0-4NH2, -(CH2)0-4NH(C1-4alkyl), -(CH2)0-4N(C1-4alkyl)2, -(CH2)0-3CH(=NOH), -NHC(=O)(CH2)1-6NH2 or -NHC(=O)(CH2)1-6NHC(=NH)(CH2)0-3H. Pharmaceutical compositions and methods of use are also disclosed.
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