OPHTHALMIC COMPOSITION CONTAINING AN ION SENSITIVE, HYDROPHILIC POLYMER AND AN INORGANIC SALT IN A RATIO WHICH GIVES LOW VISCOSITY

摘要

The present invention is directed to an ophthalmic composition in the form of a topical aqueous solution consisting essentially of: an ophthalmologically active agent containing basic groups, an ion sensitive, hydrophilic polymer containing acidic groups in an amount of 0.004 to 1.5 % by weight, at least one salt selected from the group of inorganic salts and buffers in a total amount of from 0.01 to 2.0 % by weight, and optionally a wetting agent and a preservative, the ratio between salt and polymer being such that the solution exhibits a viscosity of less than 1000 mPas, and the pH of the solution is 4.0 to 8.0. The composition contains a sufficient amount of polymer to provide for a controlled absorption of the drug into the eye, its viscosity having been reduced to provide for better handling characteristics.