Verfahren zur Herstellung von 2'-Deoxy-beta-adenosin.

摘要

The present invention relates to a process for the preparation of 2 min -deoxy- beta -adenosine industrially and easily in high yield and with high selectivity of the beta -anomer without the use of expensive raw materials or hazardous materials, by reacting a derivative of 1- -halogeno-2-deoxyribose with a derivative of adenine in the presence of a nitrogen base in 1,2,4-trichlorobenzene as a solvent to obtain 3 min ,5 min -disubstituted-2 min -deoxy- beta -adenosine and subsequently eliminating the protecting groups thereof.