发明名称 |
PROCESS FOR PREPARING 4,4-DIALKYL-6-HALO-CHROMANS OR THIOCHROMANS USEFUL AS PHARMACEUTICAL INTERMEDIATES |
摘要 |
A process of preparing intermediates useful in making compounds with retinoic acid-like activity is disclosed. The intermediates are halogenated chromans and thiochromans of the formula shown below and are prepared by the alkylation of a phenol or thiophenol with an alkene compound (the starting materials shown in the formula below), cyclization and halogenation. <IMAGE> +TR <IMAGE> In the formula the symbols have the following meanings: R1 and R2 are C1 to C4 alkyl, R3 is H or C1 to C4 alkyl, X is oxygen or sulfur, Y is a leaving group, and Z is chlorine, bromine or iodine. |
申请公布号 |
WO9519973(A3) |
申请公布日期 |
1995.10.12 |
申请号 |
WO1995US00637 |
申请日期 |
1995.01.17 |
申请人 |
ALLERGAN, INC. |
发明人 |
GARST, MICHAEL, E.;DOLBY, LLOYD, J.;FEDORUK, NESTOR, A. |
分类号 |
C07D311/58;C07D335/06 |
主分类号 |
C07D311/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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