PHARMACEUTICAL FORMULATION FOR SUBCUTANEOUS, INTRAMUSCULAR OR INTRADERMAL ADMINISTRATION OF FACTOR VIII OR FACTOR IX

摘要

The present invention relates to a pharmaceutical formulation for subcutaneous, intramuscular or intradermal administration comprising coagulation factor VIII or factor IX and use thereof for manufacture of a medicament for treating haemophilia A or B. The formulation comprises coagulation factor VIII or factor IX with an activity of at least 200 IU/ml and an additive increasing the bio-availability of factor VIII or factor IX. Tests with factor VIII gives a therapeutic level of active factor VIII in the blood stream for a surprisingly long period of time after subcutaneous, intramuscular or intradermal administration. The factor VIII is suitably a highly purified recombinant factor VIII, and preferably a deletion derivative thereof, which can be used for the manufacture of a medicament for subcutaneous administration.