发明名称 |
AGONIST ANTIBODIES AGAINST THE FLK2/FLT3 RECEPTOR AND USES THEREOF |
摘要 |
Agonist antibodies are disclosed which bind to the extracellular domain of the flk2/flt3 receptor and thereby activate the intracellular kinase domain thereof. The labeled antibodies are useful as diagnostics for detecting the presence of the flk2/flt3 receptor in primitive hematopoietic cells for example. The antibodies are able to cause primitive hematopoietic cells to proliferate and/or differentiate and thereby enhance repopulation of mature blood cell lineages in a mammal which has undergone chemo- or radiation therapy or bone marrow transplantation. The antibodies are further useful for treating mammals which have suffered a decrease in blood cells as a consequence of disease or a hemorrhage, for example.
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申请公布号 |
WO9527062(A1) |
申请公布日期 |
1995.10.12 |
申请号 |
WO1995US03718 |
申请日期 |
1995.03.23 |
申请人 |
GENENTECH, INC. |
发明人 |
BENNETT, BRIAN, D.;BROZ, SUSAN, D.;MATTHEWS, WILLIAM;ZEIGLER, FRANCIS, C. |
分类号 |
C12N15/09;A61K38/00;A61K38/16;A61K38/21;A61K38/28;A61K39/395;A61P7/00;A61P7/06;A61P37/00;A61P43/00;C07K16/28;C12N5/20;C12N15/13;C12P21/08;(IPC1-7):C12N15/13;A61K38/19 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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