| 摘要 |
An indole derivative represented by general formula (1) or a salt thereof, and a medicine containing the same (wherein R1 represents lower alkyl; R2 represents hydrogen or phenyl which may be substituted by at least one lower alkyl, lower alkoxy or halogen atom; R3 represents hydrogen, lower alkyl, lower alkoxy, or phenylalkyloxy which may be substituted by halogen or lower alkyl; R4 represents hydrogen, lower alkyl or lower alkoxy; R5 represents hydrogen or lower alkyl; and n represents an integer of 1 to 5). This compound has the effects of both blocking .alpha.1-adrenergic receptors and inhibiting testosterone 5.alpha.-reductases, and is useful as a remedy and/or a preventive for diseases caused by dihydrotestosterone overproduction, such as prostatic hypertrophy, and diseases accompanying the same, such as urination disorder, male-pattern alopecia, acne, pimple, and so forth.
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