PROCESS FOR PRODUCTION OF FINASTERIDE AND INTERMEDIATES FOR REALIZATION OF THIS METHOD

摘要

Disclosed is a new process for producing finasteride which involves reacting the magnesium halide salt of 17beta-carboalkoxy-4-aza-5alpha-androst-1-en-3-one with t-butylamino magnesium halide, present in at least a 2 : 1 molar ratio to the ester. Reaction mixture is at ambient temperature in an inert organic solvent under an inert atmosphere followed by heating and recovering the product finasteride. Also disclosed are intermediate products for realisation of this method.