发明名称 |
Protease nexin-I variants |
摘要 |
One or more amino acid residues within the reactive site region of protease nexin-I are altered in order to create analogs or variants of protease nexin-I. These analogs have substantially different protease specificities as well as different effects on regulating the activity of proteolytic enzymes which enzymes have substantial effects on a number of different physiological functions. Formulations containing the protease nexin-I variants and methods for administering these formulations to obtain desirable therapeutic results are disclosed.
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申请公布号 |
US5457090(A) |
申请公布日期 |
1995.10.10 |
申请号 |
US19920924294 |
申请日期 |
1992.08.03 |
申请人 |
INCYTE PHARAMACEUTICALS, INC. |
发明人 |
SCOTT, RANDY W.;GOLINI, FRED;MCGROGAN, MICHAEL |
分类号 |
A61K38/55;A61K38/00;A61P11/00;A61P29/00;A61P31/04;A61P43/00;C07K14/00;C07K14/81;C12N9/99;C12P21/02;C12R1/91;(IPC1-7):A61K38/55;A61K38/57 |
主分类号 |
A61K38/55 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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