VACCINES AGAINST HELMINTHIC PARASITES

摘要

The present invention provides a protective helminth parasite antigen obtainable from adult helminths characterised by: (i) in native form being in integral membrane protein; (d) having a native localisation in the parasite gut; (iii) being capable of binding to a thiol affinity medium; and (iv) being recognised by sera from immunised animal hosts, containing antibodies capable of inhibiting parasite growth and/or development, or a functionally-equivalent variant, or antigenic fragment or precursor thereof, its preparation from adult helminths, its use in vaccine compositions, DNA sequences encoding it and its production by recombinant means.