IMIDAZO(1,2-A)INDENO(1,2-E)PYRAZINE-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

摘要

Pharmaceutical compositions containing, as the active principle, compounds of formula (I), wherein R, R1 and R2 are as defined in the description, or salts thereof, the novel compounds of formula (I), and the preparation thereof, are disclosed. The compounds of formula (I) have valuable pharmacological properties and are alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists, said receptor also being known as the quisqualate receptor. Furthermore, the compounds of formula (I) are non-competitive N-methyl-D-aspartate (NMDA) receptor antagonists, and particularly NMDA receptor glycine modulation site ligands.