摘要 |
The present invention provides a protective helminth parasite antigen obtainable from adult helminths characterised by: (i) in native form being an integral membrane protein; (ii) having a native localisation in the parasite gut; (iii) being capable of binding to a thiol affinity medium; and (iv) being recognised by sera from immunised animal hosts, containing antibodies capable of inhibiting parasite growth and/or development, or a functionally-equivalent variant, or antigenic fragment or precursor thereof, its preparation from adult helminths, its use in vaccine compositions, DNA sequences encoding it and its production by recombinant means.
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申请人 |
MALLINCKRODT VETERINARY, INC.;KNOX, DAVID, PATRICK;SMITH, STUART, KEVIN;SMITH, WILLIAM, DAVID;REDMOND, DIANE;MURRAY, JACQUELINE |
发明人 |
KNOX, DAVID, PATRICK;SMITH, STUART, KEVIN;SMITH, WILLIAM, DAVID;REDMOND, DIANE;MURRAY, JACQUELINE |