| 发明名称 |
NOVEL CARBAMATES AND UREAS AS MODIFIERS OF MULTI-DRUG RESISTANCE |
| 摘要 |
The present invention relates to compounds as represented by formula (I) that can maintain, increase, or restore sensitivity of cells to therapeutic or prophylatic agents. This comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well-suited for treatment of multi-drug resistant cells, for prevention of the development of multi-drug resistance, and for use in multi-drug resistant cancer therapy.
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| 申请公布号 |
CA2186380(A1) |
申请公布日期 |
1995.10.05 |
| 申请号 |
CA19952186380 |
申请日期 |
1995.03.23 |
| 申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
ZELLE, ROBERT EDWARD;HARDING, MATTHEW W. |
| 分类号 |
A61K31/4406;A61K31/4418;A61K31/445;A61K31/47;A61K31/535;A61P43/00;C07C271/18;C07C279/10;C07C333/04;C07C335/06;C07D211/60;C07D213/30;C07D213/55;C07D401/12;C07D401/14;(IPC1-7):C07D413/12;C07D473/00;C07D471/04;C07D405/14;C07D409/14;C07D413/14;C07D417/14;A61K31/395 |
主分类号 |
A61K31/4406 |
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