发明名称 |
METHODS FOR DETECTING CALPAIN ACTIVATION AND INDENTIFYING CALPAIN INHIBITORS |
摘要 |
The invention provides methods for detecting calpain activation by measuring levels of calpain-generated spectrin BDPs using antibodies that specifically bind to these spectrin BDPs, but not intact spectrin, or spectrin BDPs generated by other proteases. Also included in the invention are kits for diagnosing diseases associated with increased levels of calpain activation, and methods for screening for effective therapeutics for these diseases.
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申请公布号 |
WO9526506(A1) |
申请公布日期 |
1995.10.05 |
申请号 |
WO1995US02279 |
申请日期 |
1995.02.21 |
申请人 |
CEPHALON, INC. |
发明人 |
SIMAN, ROBERT;BOZYCZKO-COYNE, DONNA |
分类号 |
G01N33/53;C07K7/06;C07K14/47;C07K14/81;C07K16/18;C12N9/99;G01N33/564;G01N33/573;G01N33/68;(IPC1-7):G01N33/68;G01N33/543 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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