| 摘要 |
A process for loading of cationic, anionic or ionizable drugs through lipid bilayer membranes in the absence of a pH gradient comprises the formation of liposomes in an aqueous medium containing a combination of either the salt of an anion with high membrane permeability and a cation with low membrane permeability if the compound to be entrapped is an anionic drug or has an anionic potential; or the salt of a cation with high membrane permeability and an anion with low membrane permeability if the compound to be entrapped is a cationic drug or has a cationic potential. |
