| 摘要 |
<p>PURPOSE:To obtain a new organotin compound giving an alpha-substituted cyclopentenone derivative useful especially as a synthetic intermediate for prostaglandins under neutral mild condition in a short step and high yield without causing the problems such as the use of harmful reaction reagent. CONSTITUTION:This organotin compound is expressed by formula I [X is an (alpha-OZ, beta-H) or an (alpha-H, beta-OZ) ; Y is an (alpha-OSnR<p>R<q>R<r>, beta-H) or an (alpha-H, beta- OSnR<p>R<q>R<r>); Z is H or a hydroxyl-protecting group; R<p> to R<r> each is a 1-9C alkyl, a 1-9C aralkyl, etc.], e.g. the compound of formula II (TBS is t- butyldimethylsiloxy; Bu is n-butyl). The compound can be produced by reacting an amino compound of formula III such as 2-diethylaminomethyl-4-t- butyldimethylsiloxy-2-cyclopentenone with an organotin lithium compound of formula, LiSnR<p>R<q>R<r> such as lithium tributyltin.</p> |
