| 摘要 |
<p>PURPOSE:To obtain a new compound useful as a medicine among various kinds. CONSTITUTION:The objective compound of formula I[W is (alpha-OZ<c>, beta-H) (Z<c> is a H- or OH-protecting group) or (alpha-H, beta-OZ<c>); (h) is 0-2; (m) is 0-5; Z<2> is OH, COOH, CN, H, etc.] cam be obtained by reaction between a substituted cyclopentanone derivative of formula II [X is)alpha-OZ<a>, beta-H) or (alpha-H, beta-OZ<a>); Y is (alpha-OZ<b>, beta-H) or (alpha-H, beta-OZ<b>); Z<a> and Z<b> each a OH-protecting group] and an organometallic reagent of formula III [Z<1> is OR<x> (R<x> is a OH-protecting group); CCOR<y> (R<y> is a 1-6C alkyl, a 7-10C aralkyl, etc), CN, etc.; M<1> is Li, Na, K, Mg, Ca, Ti, Ni, Cu, Zn, Al, or Sn] followed by, if desired, hydrolysis or deprotection.</p> |
