| 摘要 |
A method for producing crystals of a diester phosphate monopotassium salt, comprising (a) reacting the diester phosphate of the formula (I) <IMG> (I) with potassium hydroxide in a solvent selected from the group consisting of isopropyl alcohol, methylene chloride and chloroform and (b) allowing crystals of the diester phosphate monopotassium salt to precipitate out. The EPC-K crystals produced by the production method of the present invention have extremely fine purity and crystal appearance. Accordingly, the present invention is advantageous in that provision of pharmaceutical preparation superior in efficacy, safety and stability has been made possible.
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