发明名称 |
Menetelmä liposomaalisen prostaglandiinivalmisteen valmistamiseksi |
摘要 |
A liposome composition and methods for making same are disclosed, such compositions comprise an arachidonic acid metabolite such as a prostaglandin, preferably prostaglandin E1, a lipid, and a drying protectant such as a saccharide. The liposomes may be loaded with prostaglandin passively, or using a transmembrane concentration gradient, preferably using a transmembrane pH gradient. Using this transmembrane loading technique, trapping efficiencies of 50% to 100% are achieved, and the release rate of the prostaglandin from the liposomes is reduced. The liposome size is maintained after lyophilization and reconstitution. |
申请公布号 |
FI95199(B) |
申请公布日期 |
1995.09.29 |
申请号 |
FI19890005554 |
申请日期 |
1989.11.21 |
申请人 |
THE LIPOSOME COMPANY, INC. |
发明人 |
LENK, ROBERT P.;TOMSHO, MICHELLE M.;SUDDITH, ROBERT L.;KLIMCHAK, ROBERT J. |
分类号 |
A61K9/127;A61K31/557;A61K31/5575;(IPC1-7):A61K31/557;A61K38/00 |
主分类号 |
A61K9/127 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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