Transdermalt matrikssystem basert på en styren-isopren-styren-kopolymer for administrasjon av et östrogen og/eller et progestogen

摘要

Self-adhesive transdermal matrix material for percutaneous admin. of hormones comprises (1) a support and (2) a self-adhesive matrix comprising (by wt.): (a) 20-42 pts. triblock poly(styrene-isoprene-styrene) (SIS) copolymer; (b) 35-55 pts. tackifying resin (TR); (c) 5-25 pts. plasticiser, i.e. oleyl alcohol, peglicol-5-oleate, propyleneglycol laurate (PGL) or polypropoxylated cetyl alcohol; (d) 5-15 pts. crotamiton and/or an N-substd. 2-pyrrolidone deriv. (I); (e) 0.01-1 pt. stabiliser and (f) 0.1-5 pts. oestrogenic and/or progestational hormones.