摘要 |
<p>Modified forms of human serum albumin (HSA), wherein the arginine at position 218 is substituted by a less basic amino acid, show strong thyroxin-binding activity. These modified forms of HSA and fragments thereof are useful in binding thyroxin in standard assays for free thyroxin concentration and in treating conditions characterized by higher-than-desired levels of free thyroxin in animal subjects.</p> |