The present invention relates to a DNA expression vector comprising a T alpha l alpha -tubulin promoter operatively linked upstream to a marker gene sequence relative to the direction of transcription in a eukaryotic expression vector adapted to be introduced into a mammal, or ancestor of the mammal at an embryonic stage, and said promoter is controlling transcription of the marker gene. The present invention also relates to a method for testing material suspected of promoting neurogenesis and neuronal growth which comprises exposing a transgenic mammal according to the present invention to said material and detecting said expressed marker gene as an indication of neurogenesis and neuronal growth.
申请公布号
WO9525792(A1)
申请公布日期
1995.09.28
申请号
WO1995CA00146
申请日期
1995.03.16
申请人
MCGILL UNIVERSITY;MILLER, FREDA, DIANE;GLOSTER, ANDREW;CAUSING, CARRIE, GRACE;TOMA, JEAN, GEORGE
发明人
MILLER, FREDA, DIANE;GLOSTER, ANDREW;CAUSING, CARRIE, GRACE;TOMA, JEAN, GEORGE