| 摘要 |
Peptides corresponding to specific portions of apolipoprotein A-IV (apo A-IV) are provided. Most of the peptides correspond to the amino terminal region of apo A-IV. In addition, those peptides corresponding to the amino terminal portion of apo A-IV substantially correspond to a fundamental repeat unit of twenty two amino acids comprising: D Y F T Q L S N N A K E A V E Q L Q K T D V as well as homologs and analogs thereof. The peptides have eating suppressant properties when administered centrally or peripherally, the peptides may be used in compositions and methods for suppressing the appetite and controlling food intake. |
