Ein Verfahren zur Herstellung von einem säureergänzenden Salz von delta-Aminolevulinsäure.

摘要

An acid addition salt of delta -aminolevulinic acid is prepared in such a way that tetrahydrofurfurylamine (VI) is reacted with phthalic anhydride under an anhydrous condition to introduce a phthal group which protects amino group of tetrahydrofurfurylamine to give N-tetrahydrofurfuryl phthalimide (III), carbon atoms of the first- and fourth-positions of thus obtained N-tetrahydrofurfurylphthalimide (III) are oxidized at 80 DEG C using sodium periodate as a oxidizing agent and ruthenium chloride hydrate as a catalyst to yield 5-phthalimidolevulinic acid (II), then the protecting group of 5-phthalimidolevulinic acid (II) is deprotected using an acid to prepare an acid additional salt of delta -aminolevulinic acid. The acid additional salt of delta -aminolevulinic acid is readily converted by neutralization by an alkali to delta -aminolevulinic acid, which is very useful as a precursor of Vitamin B12, heme and chlorophyll.