Preparation of optically active cyclohexenol and cyclohexenyl acetic acid via an enzymatic process followed by a rearrangement reaction and their use as intermediates in the synthesis of indolobenzoquinoline derivatives.

摘要

A process for the production of optically active compounds of formula (VIII) and III which process comprises the following steps: (a) reaction, in the presence of a lipase, of a dl-trans-cyclohexanol compound of formula (XXI): to give an optically active compound of formula (XXIV) followed by b) an oxidation, c) an elimination and d) a hydrolyzation reaction to give the optically active compound VIII and rearranging the compound VIII with orthoester to the optically active compound III. Compounds VIII and III are intermediates in the synthesis of optically active compounds of formula I