发明名称 Method for the preparation of a phospholipid-dependent prothrombin activator from the venom of snakes
摘要 A method for the preparation of a phospholipid-dependent prothrombin activator from the venom of snakes belonging to the Elapidae family, the activator comprising an increased plasma clotting activity in the presence of phospholipids and calcium ions; a reduced activity in the presence of Lupus Anticoagulant; an ability to facilitate clotting in a normal clotting time in the presence of platelet poor plasma, the plasma having normal or decreased levels of factor V, VII, VIII, IX, or X; and a major band with a molecular weight of 40,000 to 60,000 daltons on an SDS gel.
申请公布号 US5453370(A) 申请公布日期 1995.09.26
申请号 US19920983341 申请日期 1992.11.30
申请人 PENTAPHARM AG 发明人 TRIPLETT, DOUGLAS A.;STOCKER, KURT
分类号 A61K35/58;A61P7/04;C07K14/46;C12N9/64;C12Q1/56;G01N33/53;(IPC1-7):C12N9/50;C12N9/48 主分类号 A61K35/58
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