N-PIPERIDINE-5-(4-CHLOROPHENYL)-1-(2,4-DICHLOROPHENYL)-4-METH YLPYRAZOLE-3-CARBOXAMIDE AND PHARMACEUTICALLY ACCEPTABLE SALTS AND SOLVATES THEREOF; PHARMACEUTICAL COMPOSITIONS

摘要

N-Piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyra zole-3-carboxamide of formula: its salts and solvates are powerful antagonists of central cannabinoid receptors. They are prepared by reaction of a functional derivative of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxyli c acid with 1-aminopiperidine and then optional salification.