| 摘要 |
The present invention pertains to cyclic polycationic polymer-oligonucleotide conjugates comprising a polycationic polymer covalently bonded at each end to the 3'- and 5'- terminal nucleotides of a polyanionic oligonucleotide via a cross-linking agent, wherein the polycationic polymer may be represented by the formulae: (I), or (II), or (III), or (IV) R2-[[NH(CH2)b]c[NH(CH2)d]e]f[NH(CH2)g]h-NHR2, or (V), or (VI), or (VII), or (VIII), wherein R1 through R7, X, and a through i, are defined within. |
