| 摘要 |
PCT No. PCT/SE95/00245 Sec. 371 Date Oct. 29, 1996 Sec. 102(e) Date Oct. 29, 1996 PCT Filed Mar. 8, 1995 PCT Pub. No. WO95/24196 PCT Pub. Date Sep. 14, 1995A method of treating psoriasis with a quinoline-3-carboxamide compound comprising the structure (I) below, optionally with substituents for the hydrogen atoms shown (H1-9), or a pharmaceutically acceptable salt of said compound, where (a) --- represents that there are two conjugated double bonds between the atoms comprised by the dashed line, (b) X1 and X2 are separately selected from an oxygen atom or an NH9 group, said X1 and X2 being bound by a single bond to the ring when attached to H7 or H8 and by a double bond when not bound to H7 or H8, (c) H1-9 are hydrogens with the provision that H9 is only present when at least one of X1 and X2 is the NH9-group , (d) H7 and H8 are hydrogens that are attached to different atoms selected among X1, X2 and the nitrogen atoms (N) in the quinoline ring, for the manufacture of a composition intended for treating psoriasis or conditions associated with psoriasis. Also described are methods for treating psoriasis or conditions associated with psoriasis in which methods the above compounds are administered to a living body. Particularly preferred compounds are N-phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide or a salt thereof <IMAGE> (I) |
