发明名称 |
KALLIKREIN-INHIBITING KUNITZ DOMAIN PROTEINS AND ANALOGUES THEREOF |
摘要 |
Proteins are disclosed that are homologous to bovine pancreatic trypsin inhibitor (BPTI) Kunitz domains, and especially proteins that are homologous to lipoprotein-associated coagulation inhibitor (LACI) Kunitz domains, which inhibit one or more plasma and/or tissue kallikreins, and uses of such proteins in therapeutic and diagnostic methods also are disclosed. In particular, Kunitz domains derived from Kunitz domains of human origin and especially to the first Kunitz domain of LACI are disclosed. |
申请公布号 |
WO9521601(A3) |
申请公布日期 |
1995.09.21 |
申请号 |
WO1995US00299 |
申请日期 |
1995.01.11 |
申请人 |
PROTEIN ENGINEERING CORPORATION;MARKLAND, WILLIAM;LADNER, ROBERT, CHARLES |
发明人 |
MARKLAND, WILLIAM;LADNER, ROBERT, CHARLES |
分类号 |
C12N15/09;A61K38/00;A61K38/55;A61K51/00;A61P3/00;A61P9/00;A61P29/00;A61P31/04;A61P43/00;C07K14/81;C12N15/12;C12P21/02;C12Q1/37 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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