发明名称 |
MONOCLONAL ANTIBODY RECOGNIZING FK506-BINDING PROTEIN, METHOD OF ASSAYING FK506-BINDING PROTEIN LEVEL, AND KIT THEREOF. |
摘要 |
<p>The invention relates to a monoclonal antibody (anti-FKBP antibody) which recognizes an antigenic determinant present in an FK506-binding protein (FKBP) and does not inhibit the binding between FKBP and FK506, a method of assaying a plasma FKBP level which comprises reacting an immobilized anti-FKBP antibody with an enzyme-labelled FK506 and FKBP present in a specimen and determining the extent of color development of the enzyme-substrate complex formed thereby, and a kit therefor. The invention serves to facilitate a more accurate assay of a plasma FKBP level which affects the immunosuppressive activity of FK506, whereby the optimal FK506 dose can be determined in close accordance with the condition of each individual patient.</p> |
申请公布号 |
EP0672756(A1) |
申请公布日期 |
1995.09.20 |
申请号 |
EP19940908103 |
申请日期 |
1993.08.11 |
申请人 |
FUJISAWA PHARMACEUTICAL CO., LTD. |
发明人 |
KOBAYASHI, MASAKAZU;OHTSUKA, KAZUYUKI;TANAKA, HIROKAZU;NIWA, MINEO |
分类号 |
C07K16/28;C12P21/08;(IPC1-7):C12P21/08;G01N33/68;G01N33/577 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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